PT-141 SAFETY
PT-141 Side Effects: Nausea, Blood Pressure & More
What the Vyleesi label reports
⚠ Bremelanotide can transiently raise blood pressure and is contraindicated in uncontrolled hypertension or known cardiovascular disease.
PT-141 side effects are documented in the FDA-approved label for its branded product, Vyleesi (bremelanotide). For how it works, see the PT-141 mechanism page.
Most Common Effects
Nausea was one of the most common side effects in trials and a frequent reason participants stopped treatment. Flushing and headache were also commonly reported.
Source: FDA prescribing information for VYLEESI.
Blood Pressure and Heart Rate
Bremelanotide can cause transient increases in blood pressure and reductions in heart rate after each dose. It is contraindicated in people with uncontrolled high blood pressure or known cardiovascular disease, and dosing is limited to no more than one dose in 24 hours and eight per month.
Source: FDA prescribing information for VYLEESI.
Skin Darkening
Because it acts on melanocortin pathways, focal hyperpigmentation (darkening of skin, including the face and gums) has been reported, particularly with repeated use.
Frequently Asked Questions
What is the most common PT-141 side effect?
Nausea, which was also a common reason for stopping in trials.
Who should avoid PT-141?
People with uncontrolled high blood pressure or known cardiovascular disease, per the label.
The Bottom Line
PT-141 side effects most commonly involve nausea, transient blood-pressure changes, flushing, and possible skin darkening — so PT-141 side effects warrant caution, especially with cardiovascular risk.
This article is for general educational purposes only. It is not medical advice and should not be used to diagnose, treat, or make decisions about any health condition or medication.
Primary Sources
- FDA prescribing information for VYLEESI
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