MT-1 / MELANOTAN I MECHANISM
How Does Melanotan 1 Work? The MC1R Pathway
An alpha-MSH analog that stimulates skin pigment
How does melanotan 1 work? Melanotan I, developed pharmaceutically as afamelanotide, is a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH). Its mechanism centers on skin pigment cells. For its regulatory status, see the melanotan 1 regulatory-status page.
Binding the MC1R Receptor
Melanotan I binds the melanocortin-1 receptor (MC1R) on melanocytes, the cells that produce skin pigment. Activating MC1R stimulates the production of eumelanin, the darker form of melanin, increasing pigmentation.
Source: FDA prescribing information for SCENESSE (afamelanotide).
Why This Helps in EPP
In erythropoietic protoporphyria (EPP), this increased protective pigment is thought to help reduce the painful phototoxic reactions triggered by light — the basis of the approved use. The pigmentation effect occurs largely independent of UV exposure.
Frequently Asked Questions
What receptor does melanotan 1 act on?
Mainly the melanocortin-1 receptor (MC1R) on melanocytes.
The Bottom Line
Melanotan 1 works by activating the MC1R receptor to boost eumelanin production — that pigment pathway is the core of how melanotan 1 works.
This article is for general educational purposes only. It is not medical advice and should not be used to diagnose, treat, or make decisions about any health condition or medication.
Primary Sources
- FDA prescribing information for SCENESSE (afamelanotide)
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