COMPARISON: MT-1 vs MT-2
Melanotan 1 vs Melanotan 2: Key Differences
Selectivity, approval status, and safety
Melanotan 1 vs melanotan 2 is one of the most common questions in this space, and the two are more different than the similar names suggest. This page compares them on mechanism, approval, and safety — not on which to use.
At a Glance
| Melanotan 1 | Melanotan 2 | |
|---|---|---|
| Receptor action | Mainly MC1R-selective | Non-selective (several melanocortin receptors) |
| Approved form | Yes — afamelanotide (SCENESSE) | No approved form |
| Approved use | Rare disorder (EPP), by implant | None; unapproved drug |
| Side-effect breadth | Narrower, characterized in trials | Broader; mostly case reports |
| Regulator stance | Approved product exists | Warned against by regulators |
Different Selectivity
Melanotan 1 acts mainly on the MC1R receptor tied to pigment. Melanotan 2 is non-selective, activating several melanocortin receptors — which is linked to its broader effects and broader side-effect profile.
Very Different Regulatory Standing
Melanotan 1 corresponds to an FDA-approved product (afamelanotide/SCENESSE) for a rare disease, while melanotan 2 has no approval and has been the subject of regulator warnings.
Source: FDA prescribing information for SCENESSE; TGA consumer warning on melanotan.
Frequently Asked Questions
Are melanotan 1 and melanotan 2 the same?
No. Different selectivity, and only melanotan 1 corresponds to an approved product.
Which has more documented side effects?
Melanotan 2, largely via case reports, with concerns like changes to moles.
The Bottom Line
Melanotan 1 vs melanotan 2 comes down to selectivity and regulatory standing — one is a receptor-selective approved compound, the other an unapproved, non-selective one.
This article is for general educational purposes only. It is not medical advice and should not be used to diagnose, treat, or make decisions about any health condition or medication.
Primary Sources
- FDA prescribing information for SCENESSE (afamelanotide)
- TGA consumer warning on melanotan
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